So we've talked in a previous lecture about how conserved the ribosome was we've talked a little about how it may have evolved through deep time to become this more and more complicated structure. But a more physical question that we could ask about the ribosome is how efficient or good is it at what it does. And so, one perspective on that is this idea of Landauer Bond. So what Landauer Bound is in the physics community, is a way of saying take a particular abstract computation and tell me what is the minimal amount of energy that any physical device could use to implement this abstract computation. And what that turns out to be in a general sense is Boltzmann's constant times Temperature times the change in the entropy over the course of this computation.So the Initial entropy at the beginning of the computation minus the final entropy after you've performed all the computations you care about. So we can take the ribosome and use this perspective to say something about it